Fig. 4

Mean human lineage-specific inter- (red, orange, brown) and intraspecies (blue, purple) divergence rates inside (distance to NIEB border <0) and nearby (distance to NIEB border >0) the 1,581,256 NIEBs. a Overall divergence rates; rate of interspecies (resp. intraspecies) divergence is plotted on the left-hand (resp. right-hand) y-axis. b Interspecies divergence rate in gene (light brown) and intergene (dark brown) regions. c G → A (red, blue) and C → T (orange, purple) substitution rates. d A → G (red, blue) and T → C (orange, purple) substitution rates. e C → A (red, blue) and G → T (orange, purple) substitution rates. f T → G (red, blue) and A → C (orange, purple) substitution rates. g T → A (red, blue) and A → T (orange, purple) substitution rates. h C → G (red, blue) and G → C (orange, purple) substitution rates. The vertical blue lines have the same meaning as in Fig. 1 a’–c’. In (c–h), the substitution rate on the right of the 3’ NIEB borders was averaged with its reverse complement on the left of the 5’ NIEB borders. Curves were smoothed over 10 bp windows. Non-smoothed curves are shown as a background in (a) and (b)