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Table 2 Transcripts most highly overrepresented in the seal visual cortex compared to the ferret brain

From: When the brain goes diving: transcriptome analysis reveals a reduced aerobic energy metabolism and increased stress proteins in the seal brain

Differentially expressed gene

Gene symbol

Function

Hooded seal (RPKM)

Ferret (RPKM)

Fold difference

S100 calcium binding protein B

S100B

Ca2+-binding regulator

1860.3

49.0

37.98

Osteoglycin

OGN

Growth factor

288.0

23.7

12.14

Nei endonuclease VIII-like 2

NEIL2

DNA repair

51.1

5.1

10.11

Hydroxysteroid (17-beta) dehydrogenase 11

HSD17B11

Steroid synthesis

81.3

12.6

6.46

β-2-microglobulin

B2M

Immune protein

242.1

38.7

6.26

Cytochrome P450, family 4, subfamily V, polypeptide 2

CYP4V2

Lipid metabolism

86.2

14.3

6.05

Paraoxonase 2

PON2

Antioxidant protein

95.9

17.3

5.54

Biglycan

BGN

Development and regeneration

41.1

7.7

5.35

Moesin

MSN

Membrane- cytoskeleton interaction

60.4

11.3

5.33

Transmembrane 4 L six family member 1

TM4SF1

Signal transduction

33.4

6.3

5.31

  1. Only genes with RPKM values > 5 were considered. Putative HLA-DRA genes were excluded