Table 2 Gene Ontology and KEGG pathway annotation of DEGs between two groups
Category | GO ID | GO term | P value | No.of DEGs | DEGs |
|---|---|---|---|---|---|
BP | GO:0006952 | defense response | 0.000001 | 15 | KYNU, CARD9, OLR1, RSAD2, CCL5, TLR7, TNFRSF4, CXCL10, MIF, CCR3, HRH4, PLA2G7, THBS1, MX2, RAB27A |
BP | GO:0009611 | response to wounding | 0.000008 | 13 | NRP1, OLR1, CCL5, TLR7, TPM1, TNFRSF4, CXCL10, MIF, CCR3, HRH4, PLA2G7, THBS1, RAB27A |
BP | GO:0006955 | immune response | 0.000024 | 14 | KYNU, CARD9, OLR1, IFITM3, RSAD2, CCL5, TLR7, TNFRSF4, CXCL10, MIF, IGHE, TREM2, THBS1, RAB27A |
BP | GO:0006954 | inflammatory response | 0.000027 | 10 | OLR1, CCR3, HRH4, PLA2G7, CCL5, THBS1, TNFRSF4, TLR7, MIF, CXCL10 |
BP | GO:0006690 | icosanoid metabolic process | 0.001543 | 4 | GGT5, CYP2J2, ALOX12, MIF |
BP | GO:0033559 | unsaturated fatty acid metabolic process | 0.001954 | 4 | GGT5, CYP2J2, ALOX12, MIF |
BP | GO:0009615 | response to virus | 0.001958 | 5 | CARD9, RSAD2, CCL5, MX2, TLR7 |
BP | GO:0006631 | fatty acid metabolic process | 0.002770 | 6 | LPL, GGT5, CYP2J2, CPT1A, ALOX12, MIF |
BP | GO:0032940 | secretion by cell | 0.003353 | 6 | STX1A, LMF1, USE1, CCL5, RAB27A, CXCL10 |
BP | GO:0051607 | defense response to virus | 0.004209 | 3 | CARD9, RSAD2, TLR7 |
BP | GO:0006633 | fatty acid biosynthetic process | 0.006735 | 4 | LPL, GGT5, ALOX12, MIF |
BP | GO:0046394 | carboxylic acid biosynthetic process | 0.006891 | 5 | LPL, GGT5, KYNU, ALOX12, MIF |
BP | GO:0016053 | organic acid biosynthetic process | 0.006891 | 5 | LPL, GGT5, KYNU, ALOX12, MIF |
BP | GO:0046456 | icosanoid biosynthetic process | 0.009951 | 3 | GGT5, ALOX12, MIF |
BP | GO:0006636 | unsaturated fatty acid biosynthetic process | 0.011894 | 3 | GGT5, ALOX12, MIF |
BP | GO:0008015 | blood circulation | 0.012860 | 5 | TCAP, OLR1, MYOF, TPM1, CXCL10 |
BP | GO:0003013 | circulatory system process | 0.012860 | 5 | TCAP, OLR1, MYOF, TPM1, CXCL10 |
BP | GO:0051270 | regulation of cell motion | 0.014554 | 5 | COL18A1, NRP1, THBS1, TPM1, CXCL10 |
BP | GO:0046903 | secretion | 0.015412 | 6 | STX1A, LMF1, USE1, CCL5, RAB27A, CXCL10 |
BP | GO:0016192 | vesicle-mediated transport | 0.021730 | 8 | STX1A, RABEP2, HIP1R, USE1, TRAPPC5, CCL5, THBS1, RAB27A |
BP | GO:0002252 | immune effector process | 0.027651 | 4 | CARD9, RSAD2, TLR7, RAB27A |
BP | GO:0002684 | positive regulation of immune system process | 0.028807 | 5 | CARD9, IL13RA1, THBS1, TNFRSF4, TLR7 |
BP | GO:0002544 | chronic inflammatory response | 0.028923 | 2 | CCL5, THBS1 |
BP | GO:0045087 | innate immune response | 0.029812 | 4 | KYNU, TLR7, RAB27A, MIF |
BP | GO:0051240 | positive regulation of multicellular organismal process | 0.031168 | 5 | CARD9, CCL5, THBS1, TPM1, TLR7 |
BP | GO:0045785 | positive regulation of cell adhesion | 0.034610 | 3 | THBS1, TPM1, ALOX12 |
BP | GO:0006968 | cellular defense response | 0.035673 | 3 | CCR3, CCL5, TNFRSF4 |
BP | GO:0033273 | response to vitamin | 0.041171 | 3 | ALPL, KYNU, PMF1 |
BP | GO:0002694 | regulation of leukocyte activation | 0.047354 | 4 | IL13RA1, THBS1, TNFRSF4, MIF |
BP | GO:0031349 | positive regulation of defense response | 0.049365 | 3 | CARD9, CCL5, TLR7 |
BP | GO:0030334 | regulation of cell migration | 0.049479 | 4 | COL18A1, THBS1, TPM1, CXCL10 |
BP | GO:0000267 | cell fraction | 0.002965 | 13 | STX1A, KYNU, CYB5R2, CYP2J2, OLR1, HIP1R, SLC6A4, CCL5, CPT1A, PYGM, HRH4, ABCC4, CA4 |
CC | GO:0005886 | plasma membrane | 0.009603 | 27 | ALPL, STEAP4, NRP1, IFITM3, SLC6A4, SLC16A12, RSAD2, TNFRSF4, TPM1, HRH4, TGM3, THBS1, IL13RA1, MYOF, RAB27A, LPL, STX1A, OLR1, ZP3, FADD, GGT5, TARP, CCR3, CA4, ABCC4, TREM2, ALOX12 |
CC | GO:0044433 | cytoplasmic vesicle part | 0.010180 | 5 | STX1A, HIP1R, ABCC4, THBS1, RAB27A |
CC | GO:0030659 | cytoplasmic vesicle membrane | 0.025142 | 4 | STX1A, HIP1R, ABCC4, RAB27A |
CC | GO:0044421 | extracellular region part | 0.027958 | 10 | COL18A1, LPL, OGN, ZP3, PLA2G7, PMF1, CCL5, THBS1, MIF, CXCL10 |
CC | GO:0005624 | membrane fraction | 0.028767 | 9 | STX1A, CYP2J2, OLR1, HIP1R, HRH4, SLC6A4, ABCC4, CA4, CPT1A |
CC | GO:0012506 | vesicle membrane | 0.031088 | 4 | STX1A, HIP1R, ABCC4, RAB27A |
CC | GO:0005615 | extracellular space | 0.034524 | 8 | COL18A1, LPL, PLA2G7, PMF1, CCL5, THBS1, MIF, CXCL10 |
CC | GO:0005626 | insoluble fraction | 0.034688 | 9 | STX1A, CYP2J2, OLR1, HIP1R, HRH4, SLC6A4, ABCC4, CA4, CPT1A |
CC | GO:0030141 | secretory granule | 0.048228 | 4 | STX1A, ABCC4, THBS1, RAB27A |
MF | GO:0019955 | cytokine binding | 0.013930 | 4 | CCR3, IL13RA1, THBS1, TNFRSF4 |
MF | GO:0008144 | drug binding | 0.028489 | 3 | PYGM, SLC6A4, TLR7 |
KEGG PATHWAY | hsa04620 | Toll-like receptor signaling pathway | 0.029157 | 4 | FADD, CCL5, TLR7, CXCL10 |