Fig. 1

Simulation on the distribution of CCI and its relationship with noise in the data. Top: Relationship between CCI and noise level. The x-axis reflects the effects of the noise on the centralized matrix. Middle: The distribution of CCI calculated from 1000 randomly selected gene lists (with 220 genes) in the 41 lung cancer tumor samples (using GSE18842). Bottom: The distribution of CCI calculated from 1000 random permutation of the data from the correlated gene module