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Table 1 Enrichment analysis of the 15 gene modules that are specific to tumor samples in lung cancer
| Module | Size | GO BP term (p-value) | Cytoband (p-value) | TF (p-value) |
|---|---|---|---|---|
| 4 | 162 | Epidermis development (p = 8.762E-23); | 1q21-q22 (p = 3.354E-06); | AP1 (p = 2.177E-04, 22 genes); |
| 2p24.3 (p = 5.021E-06) | AREB6 (p = 9.900E-04, 8 genes) | |||
| 5 | 159 | neuron differentiation (p = 1.516E-07); | 6q14.2 (p = 1.796E-04); | PAX4 (p = 1.046E-05, 9 genes); |
| generation of neurons (p = 2.105E-07) | 5q33 (p = 2.686E-04) | MSX1 (p = 2.088E-04, 7 genes) | ||
| 9 | 98 | Neurogenesis (p = 1.490E-06); | MSX1 (p = 2.875E-06, 7 genes); | |
| central nervous system development (p = 2.543E-06) | RNGTGGGC UNKNOWN (p = 3.383E-05, 11 genes) | |||
| 17 | 62 | meiotic nuclear division (p = 1.035E-04); | 7p15.3-p15.1 (p = 1.676E-03); | |
| meiotic cell cycle (p = 1.349E-04) | 12q22-q24.1 (p = 1.676E-03) | |||
| 19 | 55 | cellular glucuronidation (p = 2.634E-05); | 4q13 (p = 2.202E-04); | |
| uronic acid metabolic process (p = 3.005E-05) | 4q31.3-q32 (p = 1.474E-03) | |||
| 25 | 48 | glutamate decarboxylation to succinate (p = 4.577E-06); | 4q21.22 (p = 1.646E-06); | |
| glutamate catabolic process (p = 9.526E-05) | 8p11.22 (p = 1.485E-04) | |||
| 38 | 36 | calcium ion export (p = 2.626E-05) | 7q21.3 (p = 8.602E-06); | |
| 9p21.3 (p = 2.647E-04) | ||||
| 44 | 33 | vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure (p = 2.381E-06); | 7p12.2 (p = 1.729E-05); | RORA1 (p = 6.429E-03, 3 genes); |
| baroreceptor response to increased systemic arterial blood pressure (p = 1.424E-05) | 11p15.2-p15.1 (p = 9.241E-04) | ERR1 (p = 7.357E-03, 3 genes) | ||
| 50 | 30 | fatty acid derivative metabolic process (p = 1.751E-07); | 4q28-q32 (p = 1.673E-03) | WGTTNNNNNAAA UNKNOWN (p = 2.278E-03, 4 genes); |
| icosanoid metabolic process (p = 1.751E-07) | FOXO4 (p = 1.168E-02, 6 genes) | |||
| 66 | 21 | 4p16.3 (p = 2.197E-9, 5 genes); 13 genes on 4p13-16 | E2F1 (p = 9.854E-4, 3 genes) | |
| 67 | 21 | 9q21.33 (p = 5.973E-05); | RACTNNRTTTNC UNKNOWN (p = 3.031E-05, 3 genes) | |
| 9q22.32 (p = 1.652E-04); 18 genes on 9q21-34 | ||||
| 70 | 20 | 1q22-q23.2 (p = 5.196E-04) | ||
| 8q22-q23 (p = 1.038E-03) | ||||
| 81 | 18 | 21q22.3 (p = 2.655E-05) | ||
| 84 | 18 | 4q31.23 (p = 6.329E-06); 4q31 (p = 1.242E-05); 12 genes on 4q23-31 | CREB (p = 1.568E-04, 3 genes) | |
| 116 | 13 | Xp11.23 (p = 6.422E-04) | MEIS1 (p = 1.089E-03, 3 genes) |
