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Table 1 Predicted A. burtoni prohormone families and duplication status

From: Identification of prohormones and pituitary neuropeptides in the African cichlid, Astatotilapia burtoni

Neuropeptide Family N Ga N Db Gene Symbolsc References
Apelin 1 0 APLN [70]
Augurin 1 0 AUGN  
AVIT/Prokineticin 2 0 PROK1; PROK2  
Bombesin/Neuromedin-B/Ranatensin 3 2 GRP; NMB1; NMB2 [113]
Calcitonin 8 4 ADM1A; ADM1B; ADM2A; ADM2B; ADM5; CALCA; CALCB; IAPP [114]
CART 6 6 CARTPT1; CARTPT2; CARTPT3; CARTPT4; CARTPT5; CARTPT6 [71]
clpA/clpB family. Torsin subfamily. 1 0 TOR2A  
Corticotrophin 5 2 CRH1A; CRH1B; UCN2; UCN3; UTS1 [50, 115117]
Endothelin/Sarafotoxin 6 6 EDN1A; EDN1B; EDN2A; EDN2B; EDN3A; EDN3B [118]
Gastrin/Cholecystokinin 3 2 CCK1; CCK2; GAST [119]
Ghrelin/Motilin-related 2 0 GHRL; MLN [119, 120]
Glucagon 8 4 ADCYAP1A; ADCYAP1B; GCG1A; GCG1B; GCG2; GHRH; GIP; VIP [35, 37, 121]
Gonadotropin-releasing hormone 3 0 GNRH1; GNRH2; GNRH3 d [28, 122124]
Granin 9 4 CHGA; CHGB; PCSK1N; SCG2A; SCG2B; SCG3; SCG5; VGF1; VGF2 [73, 125, 126]
Hepcidin 5 5 HAMP1; HAMP2; HAMP3; HAMP4; HAMP5 [68]
Insulin 5 2 IGF1; IGF2; IGF3 d; INS1; INS2 [32, 127]
Kisspeptin/Galanin/Spexin 4 2 KISS2 d; GAL; SPX1; SPX2 [61, 62, 128130]
Melanin-concentrating hormone 2 2 PMCH1; PMCH2 [131]
Natriuretic peptide 6 4 NPPA; NPPB; NPPC1; NPPC2; NPPC3; NPPC4 [70]
Neuropeptide B/W 2 2 NPB1; NPB2 [53]
Neurotensin 1 0 NTS  
Neuromedin 2 0 NMS; NMU [132]
Neuropeptide Y 4 4 NPY1; NPY2; PYY1; PYY2 [54, 55]
Nucleobindin 3 2 NUCB1; NUCB2A; NUCB2B  
Opioid 7 5 PDYN; PENK; PNOC1; PNOC2; POMC1A; POMC1B; POMC2 [4648, 104, 133135]
Orexin 1 0 HCRT [136]
Osteocrin 1 0 OSTN  
Oxytocin/Vasopressin 2 0 AVP; OXT; [137]
Parathyroid 6 4 PTH1A; PTH1B; PTH2; PTHLH1; PTHLH2; PTHLH3 d [57, 58, 138, 139]
PDGF/VEGF growth factor 13 10 FIGF; PDGFA1; PDGFA2; PDGFB1; PDGFB2; PDGFC; PDGFD; PGF1; PGF2; VEGFA1; VEGFA2; VEGFC1; VEGFC2 [33, 34]
Relaxin 6 4 INSL3; INSL5A; INSL5B; RLN1; RLN3A; RLN3B [33, 34, 140]
Rfamide peptide 5 2 NPFF; NPVF; QRFP; PRLH1; PRLH2 [141143]
Somatostatin/Urotensin 8 4 SST1; SST2; SST3; SST5; URP1 d; URP2 d; UTS2A; UTS2B [39, 40]
Tachykinin 6 6 TAC1A; TAC1B; TAC3A; TAC3B; TAC4A; TAC4B [144]
Thyrotropin-releasing hormone 1 0 TRH [145]
  1. aN G: Number of identified gene sequences within family
  2. bN D: Number of identified gene sequences within family that have been duplicated
  3. cGene Symbol: Based on Homo sapiens gene symbols where probable duplicated genes are denoted with either a number or lower case letter. Full gene names and symbols are provided in Additional file 2
  4. dProhormones lacking direct mammalian counterparts