Table 1 Predicted A. burtoni prohormone families and duplication status

Apelin

1

0

APLN

[70]

Augurin

1

0

AUGN

AVIT/Prokineticin

2

0

PROK1; PROK2

Bombesin/Neuromedin-B/Ranatensin

3

2

GRP; NMB1; NMB2

[113]

Calcitonin

8

4

ADM1A; ADM1B; ADM2A; ADM2B; ADM5; CALCA; CALCB; IAPP

[114]

CART

6

6

CARTPT1; CARTPT2; CARTPT3; CARTPT4; CARTPT5; CARTPT6

[71]

clpA/clpB family. Torsin subfamily.

1

0

TOR2A

Corticotrophin

5

2

CRH1A; CRH1B; UCN2; UCN3; UTS1

[50, 115–117]

Endothelin/Sarafotoxin

6

6

EDN1A; EDN1B; EDN2A; EDN2B; EDN3A; EDN3B

[118]

Gastrin/Cholecystokinin

3

2

CCK1; CCK2; GAST

[119]

Ghrelin/Motilin-related

2

0

GHRL; MLN

[119, 120]

Glucagon

8

4

ADCYAP1A; ADCYAP1B; GCG1A; GCG1B; GCG2; GHRH; GIP; VIP

[35, 37, 121]

Gonadotropin-releasing hormone

3

0

GNRH1; GNRH2; GNRH3 ^d

[28, 122–124]

Granin

9

4

CHGA; CHGB; PCSK1N; SCG2A; SCG2B; SCG3; SCG5; VGF1; VGF2

[73, 125, 126]

Hepcidin

5

5

HAMP1; HAMP2; HAMP3; HAMP4; HAMP5

[68]

Insulin

5

2

IGF1; IGF2; IGF3 ^d; INS1; INS2

[32, 127]

Kisspeptin/Galanin/Spexin

4

2

KISS2 ^d; GAL; SPX1; SPX2

[61, 62, 128–130]

Melanin-concentrating hormone

2

2

PMCH1; PMCH2

[131]

Natriuretic peptide

6

4

NPPA; NPPB; NPPC1; NPPC2; NPPC3; NPPC4

[70]

Neuropeptide B/W

2

2

NPB1; NPB2

[53]

Neurotensin

1

0

NTS

Neuromedin

2

0

NMS; NMU

[132]

Neuropeptide Y

4

4

NPY1; NPY2; PYY1; PYY2

[54, 55]

Nucleobindin

3

2

NUCB1; NUCB2A; NUCB2B

Opioid

7

5

PDYN; PENK; PNOC1; PNOC2; POMC1A; POMC1B; POMC2

[46–48, 104, 133–135]

Orexin

1

0

HCRT

[136]

Osteocrin

1

0

OSTN

Oxytocin/Vasopressin

2

0

AVP; OXT;

[137]

Parathyroid

6

4

PTH1A; PTH1B; PTH2; PTHLH1; PTHLH2; PTHLH3 ^d

[57, 58, 138, 139]

PDGF/VEGF growth factor

13

10

FIGF; PDGFA1; PDGFA2; PDGFB1; PDGFB2; PDGFC; PDGFD; PGF1; PGF2; VEGFA1; VEGFA2; VEGFC1; VEGFC2

[33, 34]

Relaxin

6

4

INSL3; INSL5A; INSL5B; RLN1; RLN3A; RLN3B

[33, 34, 140]

Rfamide peptide

5

2

NPFF; NPVF; QRFP; PRLH1; PRLH2

[141–143]

Somatostatin/Urotensin

8

4

SST1; SST2; SST3; SST5; URP1 ^d; URP2 ^d; UTS2A; UTS2B

[39, 40]

Tachykinin

6

6

TAC1A; TAC1B; TAC3A; TAC3B; TAC4A; TAC4B

[144]

Thyrotropin-releasing hormone

1

0

TRH

[145]