Table 7 Novel singular aa positions associated to host adaptation

HA

6,9,10,14,23,47,66,69,78,88,91,94,130,173,189,200,220,222,435,516

M1

30,116,142,207,209

M2

13,16,31,36,43,51,54

NA

16,18,19,23,30,40,42,44,46,47,74,79,147,150,157,166,232,285,341,344,351,369,372,389,397,435,437,466

NP

31,53,98,146,444,450,498

NS1

6,7,14,23,27,28,74,123,152,192,220,226

NS2

6,7,14,32,34,48,83,86

PA

85,323,336,348,362,300

PAX

28,85,210,233

PB1

12,54,59,113,175,212,339,435,576,586,587,619,709

PB1F2

3,6,12,17,21,25,26,27,28,33,47,52,54,57,58,60,62,65,82

PB2

54,65,354