Fig. 4
From: Orthologs, turn-over, and remolding of tRNAs in primates and fruit flies
Scheme of step-wise orthology identification. Top genomic organization of tRNAs (colored symbols). “Secure anchors” such as known orthologous proteins are shown as gray ovals. Sequence-unique alignment blocks are indicated as thick dark-gray lines. These anchors subdivide the genome into syntenic clusters forming the connected components of the graph of candidates Γ c , here shown for blocks of a genome-wide alignment as delimiters. Each cluster forms a connected component of Γ c . Pairwise generalized list alignments leads to an estimate of the co-orthology relation for each group of homologous tRNAs. Each of these estimated graphs is then corrected to the nearest cograph