Genetic mapping of canine fear and aggression

BMC Genomics

Table 1 Summary of canine fear and aggression GWAS results. Fear and aggression trait peaks are given for separate GWAS studies using Vaysse (marked “V”; Illumina HD) and Boyko (“B”; Affymetrix v.2) genotype datasets. Loci shared with both are black and others are gray. Coordinates use CanFam2 assembly

^a-dThe peak SNPs chrX:105,245,495, chrX:105,770,058, chrX:105,877,339, and chrX:106,189,665 (numbered ^a-d in superscript, respectively) lie within one LD block. At least SNPs 2 and 3 are presumed to implicate the same haplotype/functional variant; candidate genes refer to these peaks
^eThe peak SNP is 23,298,242 (vs. chr18:23,260,370 for the others)
^fThe peak SNP for Vaysse is chr10:11,169,956 and for Boyko is chr10:10,859,628
^gVaysse peak SNP chr15:44,258,017; Boyko peak SNP chr15:44,226,659
^hPeak SNP is a coding variant at a generally mammalian-conserved position
ⁱ ARHGAP36, IGSF1 and long non-coding RNA FIRRE are co-expressed, including in the pituitary gland and hypothalamus (see text)

ISSN: 1471-2164