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Fig. 9 | BMC Genomics

Fig. 9

From: Whole-genome regulation analysis of histone H3 lysin 27 trimethylation in subclinical mastitis cows infected by Staphylococcus aureus

Fig. 9

Hypothesis of “The regulation of H3K27me3 on S. aureus subclinical mastitis susceptibility in dairy cows lymphocytes”. This cartoon shows the interaction of signaling networks induced by S. aureus infection including MHC I pathway, T cell receptor pathway and cytokines-cytokine receptor interaction signaling pathway, in which γ-interferon mediates MHC I to act on CD8 T cells and nature killer cells for killing the target cells. Cytokine genes IL10, IL13RA1 and CXCL10 participate in the synthesis of γ-interferon. ARG1 gene is involved in cell responses to identify S. aureus and then induces the immune interaction. However, H3K27me3 regulates expressions of these key genes in this immune signaling network

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