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Table 2 Functional enrichment analysis of gene ontology (GO) terms regulated by falcarinol and panaxydol (P-value < 0.01 after post-hoc analysis)

From: Determining the mode of action of anti-mycobacterial C17 diyne natural products using expression profiling: evidence for fatty acid biosynthesis inhibition

Treatment

Gene ontology category

GO term

Name

Frequency

PAGE Z-Score

P-value

Falcarinol

Molecular function

go:0008658

Penicillin binding

14

5.4

3.0E-05

Molecular function

go:0004674

Protein serine/threonine kinase activity

21

5.3

3.6E-05

Molecular function

go:0003735

Structural constituent of ribosome

58

5.2

3.9E-05

Biological process

go:0045227

Capsule polysaccharide biosynthetic process

7

5.0

6.3E-05

Biological process

go:0009088

Threonine biosynthetic process

5

4.9

6.9E-05

Biological process

go:0019491

Ectoine biosynthetic process

3

4.9

6.9E-05

Biological process

go:0043952

Protein transport by the Sec complex

3

4.9

6.9E-05

Biological process

go:0051188

Cofactor biosynthetic process

3

4.9

6.9E-05

Biological process

go:0065002

Intracellular protein transmembrane transport

3

4.9

6.9E-05

Biological process

go:0006412

Translation

67

4.4

5.0E-04

Cellular component

go:0009360

DNA polymerase III complex

6

4.3

8.6E-04

Cellular component

go:0005840

Ribosome

46

4.1

1.7E-03

Molecular function

go:0003697

Single-stranded DNA binding

7

3.9

5.1E-03

Molecular function

go:0019843

rRNA binding

36

3.7

9.5E-03

Molecular function

go:0008825

Cyclopropane-fatty-acyl-phospholipid synthase activity

7

2.7

9.6E-03

Panaxydol

Molecular function

go:0019843

rRNA binding

36

5.7

8.1E-06

Molecular function

go:0003735

Structural constituent of ribosome

58

5.5

8.3E-06

Biological process

go:0006412

Translation

67

4.7

4.6E-04

Biological process

go:0008610

Lipid biosynthetic process

9

4.5

9.3E-04

Cellular component

go:0005840

Ribosome

46

4.4

1.1E-03

Molecular function

go:0008825

Cyclopropane-fatty-acyl-phospholipid synthase activity

7

4.3

1.3E-03

Biological process

go:0019491

Ectoine biosynthetic process

3

4.3

1.3E-03

Biological process

go:0043952

Protein transport by the Sec complex

3

4.3

1.3E-03

Biological process

go:0065002

Intracellular protein transmembrane transport

3

4.3

1.3E-03

Molecular function

go:0004674

Protein serine/threonine kinase activity

21

3.8

9.6E-03