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Table 2 Functional enrichment analysis of gene ontology (GO) terms regulated by falcarinol and panaxydol (P-value < 0.01 after post-hoc analysis)

From: Determining the mode of action of anti-mycobacterial C17 diyne natural products using expression profiling: evidence for fatty acid biosynthesis inhibition

Treatment Gene ontology category GO term Name Frequency PAGE Z-Score P-value
Falcarinol Molecular function go:0008658 Penicillin binding 14 5.4 3.0E-05
Molecular function go:0004674 Protein serine/threonine kinase activity 21 5.3 3.6E-05
Molecular function go:0003735 Structural constituent of ribosome 58 5.2 3.9E-05
Biological process go:0045227 Capsule polysaccharide biosynthetic process 7 5.0 6.3E-05
Biological process go:0009088 Threonine biosynthetic process 5 4.9 6.9E-05
Biological process go:0019491 Ectoine biosynthetic process 3 4.9 6.9E-05
Biological process go:0043952 Protein transport by the Sec complex 3 4.9 6.9E-05
Biological process go:0051188 Cofactor biosynthetic process 3 4.9 6.9E-05
Biological process go:0065002 Intracellular protein transmembrane transport 3 4.9 6.9E-05
Biological process go:0006412 Translation 67 4.4 5.0E-04
Cellular component go:0009360 DNA polymerase III complex 6 4.3 8.6E-04
Cellular component go:0005840 Ribosome 46 4.1 1.7E-03
Molecular function go:0003697 Single-stranded DNA binding 7 3.9 5.1E-03
Molecular function go:0019843 rRNA binding 36 3.7 9.5E-03
Molecular function go:0008825 Cyclopropane-fatty-acyl-phospholipid synthase activity 7 2.7 9.6E-03
Panaxydol Molecular function go:0019843 rRNA binding 36 5.7 8.1E-06
Molecular function go:0003735 Structural constituent of ribosome 58 5.5 8.3E-06
Biological process go:0006412 Translation 67 4.7 4.6E-04
Biological process go:0008610 Lipid biosynthetic process 9 4.5 9.3E-04
Cellular component go:0005840 Ribosome 46 4.4 1.1E-03
Molecular function go:0008825 Cyclopropane-fatty-acyl-phospholipid synthase activity 7 4.3 1.3E-03
Biological process go:0019491 Ectoine biosynthetic process 3 4.3 1.3E-03
Biological process go:0043952 Protein transport by the Sec complex 3 4.3 1.3E-03
Biological process go:0065002 Intracellular protein transmembrane transport 3 4.3 1.3E-03
Molecular function go:0004674 Protein serine/threonine kinase activity 21 3.8 9.6E-03