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Table 3 Pathway enrichment analysis for pathways regulated by falcarinol and panaxydol (P-value < 0.01) after post-hoc analysis and significantly different genes related to the pathways

From: Determining the mode of action of anti-mycobacterial C17 diyne natural products using expression profiling: evidence for fatty acid biosynthesis inhibition

Treatment Pathways P-value Genes in Pathway
Falcarinol Threonine biosynthesis 5.3E-05 MSMEG 6286, thrC, thrB, MSMEG 4957, asd, MSMEG6257
Ectoine biosynthesis 6.1E-05 asd, MSMEG 6257, ectC, ectA, ectB
Superpathway of methionine biosynthesis (by sulfhydrylation) 4.4E-04 MSMEG 4528, metE, metX, MSMEG 1652, MSMEG 4657, asd, MSMEG 6257, MSMEG 6286
Isoleucine biosynthesis I 4.4E-04 ilvA, ilvH, thrC, thrB, MSMEG 4657, asd, MSMEG 6257, MSMEG 6286
Methionine Biosynthesis 2.0E-03 metE, MSMEG 4957, asd, MSMEG 6257, MSMEG 6286, MSMEG 4528, metX, MSMEG 1652
Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis 2.1E-03 MSMEG 6386, MSMEG 6399, MSMEG 6382, MSMEG 6401, glf, MSMEG 4947
Homoserine biosynthesis 3.0E-03 MSMEG 4957, asd, MSMEG 6257
Superpathway of methionine biosynthesis (transsulfuration) 4.7E-03 metE, MSMEG 4957, asd, MSMEG 6257, MSMEG 6286
Unusual Fatty Acid Biosynthesis 5.5E-03 MSMEG 1350, MSMEG 1351, MSMEG 3538
Cyclopropane Fatty Acids Biosynthesis 9.3E-03 MSMEG 1350, MSMEG 1351, MSMEG 3538
Panaxydol Ectoine biosynthesis 3.8E-03 MSMEG 6257, ectC, ectA, ectB
Urea degradation II 3.8E-03 MSMEG 1093, ureC, ureB, ureA
Pyruvate fermentation to acetate VII 5.1E-03 pta, ackA, MSMEG 4646
Pyruvate fermentation to acetate I 5.1E-03 pta
Methionine Biosynthesis 6.3E-03 metE, metN, MSMEG 6257, MSMEG 6286, MSMEG 4528, MSMEG 4527, metXm MSMEG 1652
Superpathway of methionine biosynthesis (by sulfhydrylation) 7.7E-03 MSMEG 4528, MSMEG 4527, metE, metX, MSMEG 1652, MSMEG 6257, MSMEG 6286
Unusual Fatty Acid Biosynthesis 9.7E-03 MSMEG 1205, MSMEG 1350, MSMEG 1351, MSMEG 3538
Cyclopropane Fatty Acids Biosynthesis 9.7E-03 MSMEG 1205, MSMEG 1350, MSMEG 1351, MSMEG 3538
Urate biosynthesis/inosine 5′-phosphate degradation 9.7E-03 MSMEG 1701, MSMEG 4308, guaB, MSMEG 1603