Fig. 5

Gene expression patterns in S. mansoni infected mice. Hierarchical clustering identified two major expression patterns (up-regulation and down-regulation in infected mice compared to control uninfected mice), containing 9 different clusters. Gene expression patterns are observed between high infected (H1, H2) and low infected (L1, L2) mice. Gene expression patterns are represented as a heat map with relatively unchanged genes in black, down regulated genes in light blue and up regulated genes in dark blue. Clusters were annotated using DAVID and REVIGO functional annotation tools [45, 47]. U1U2: uninfected controls, L1L2: infected, low parasite burden, H1H2: infected, high parasite burden. Trinity de novo assembly was used