Pangenome and immuno-proteomics analysis of Acinetobacter baumannii strains revealed the core peptide vaccine targets

Table 2 Significant virulence factors in A. baumannii strains

Virulence factors	International Clone I				International Clone II						Function
	A. baumannii				A. baumannii
	AYE	A1	AB0057	AB307-0294	ACICU	MDRTJ	MDR-ZJ06	TCDC-AB0715	1656	BJAB0868
Intl1	+	+	+	-	+	+	+	+	+	-	Tn21 integrase
aadA1	+	+	+	-	-	+	+	+			Streptomycin adenyltransferase
Cat	+	+	+	-	-	+	-	-			Chloramphenicol acetyltransferase
tnpM	+	+	+	-	+	+	+	+	-	-	TnmP
tnpA	+	+	+	-	-	-	-	-	-	-	Transposase
tnpH	+	+	+		-	-	-	-	-	-	Hypothetical protein
htpB	-	-	-	+	+	-	+	+	+	+	Heat shock protein60
manB	-	-	-	+	+	-	+	+	+	+	Phosphomannumutase
pilF	-	-	-	-	+	+	-	-	+	+	Type4 pilus assembly protein
tetR	-	-	-	-	-	+	+	+	-	+	Tet repressor
tetAB	-	-	-	-	-	+	+	+	-	+	Tetracycline resistance protein

The signs + and – in the table denote presence or absence of genes, respectively. BLASTp search on Virulence factor database (VFdb) revealed sharing of common virulence factors in A. baumannii strains belonging to the international clone I and II. Virulence factors like Tn21 integrase and streptomycin adenyltransferase are frequently shared by strains of both international clone I and II. Transposases (tnpA, tnpH) and chloramphenicol acetyltransferases are mostly expressed in strains A.baumannii AYE, A.baumannii A1 and A.baumannii 0057 of IC I. Occurrence of specific virulence factors in IC I and IC II illustrates the evolution of the bacteria as the super bug in certain geographical locations and its survival in localized environments

ISSN: 1471-2164