Fig. 5
From: The beagle dog MicroRNA tissue atlas: identifying translatable biomarkers of organ toxicity
POC Compound X histopathology review and candidate safety biomarker assessment. a Representative hematoxylin and eosin stained liver histopathology sections. Liver damage severity was scored by histopathologic review as Minimal, Mild, or Moderate. b Serum levels of ALT and AST in animals that received Compound X or vehicle control. The colored boxes on the left correspond to the severity of liver injury. c Serum levels of miR-122 and miR-885 in animals dosed with Compound X compared to vehicle. Samples were collected at the indicated time points on Day 7 of dosing. The line color corresponds to the severity of damage