Identification of protein-damaging mutations in 10 swine taste receptors and 191 appetite-reward genes

BMC Genomics

Table 5 Genes with variants showing significantly different pAAF between F2_F and F2_L

Gene	Total number	Number and type of variants with significant differences is pAAF	Fisher Test value range (min-max)
ADRB1	1	1 synonymous	0.0467
ALDH1B1	3	3 synonymous	0.0253
ALDH2	1	1 non-synoymous tolerated	0.0358
ALDH3B2	7	1 non-synoymous deleterious; 6 synonymous	0.0003–0.0137
ALDH6A1	1	1 synonymous	0.0253
CD36	3	1 frame-shift; 1 non-synoymous deleterious; 1 synonymous	1.5xE-05^a - 2.58xE-05^a
DISC1	3	3 synonymous	0.0280–0.0357
TVPR1 human ortholog (ENSSSCG00000017863)	5	1 non-synoymous deleterious; 4 synonymous	0.0111–0.0315
ALDH8A1 ortholog (ENSSSCG00000023457)	1	1 synonymous	0.0387
FOS	2	1 non-synoymous tolerated; 1 synonymous	0.0284
GABRA3	1	1 splice-site donor/acceptor	0.0253
GABRA6	1	1 synonymous	0.0047
GPR179	9	2 non-synoymous deleterious; 4 non-synoymous tolerated; 3 synonymous	0.0137–0.0324
GPRC5B	1	1 non-synoymous deleterious	0.0253
GPRC5C	1	1 non-synoymous tolerated	0.0258
GRM1	3	3 synonymous	0.0047–0.0383
GRM8	1	1 synonymous	0.0178
HTR1B	1	1 synonymous	0.0253
HTR3C	1	1 synonymous	0.0357
LEPR	1	1 synonymous	0.0253
MCHR2	2	2 synonymous	0.0115–0.0253
MTNR1B	1	1 non-synoymous tolerated	0.0357
P2RX2	2	2 synonymous	0.0094–0.0324
P2X7	3	3 synonymous	0.0006–0.0324
SIM1	1	1 synonymous	0.0115
TAS2R16 ortholog (ENSSSCG00000016433)	1	1 synonymous	0.0315
TAS2R39	1	1 codon change	6.16xE-08^a
TAS2R4	4	2 non-synoymous tolerated; 2 synonymous	0.0002–0.0158
TAS2R41	1	1 non-synoymous tolerated	0.0207
TAS2R60	1	1 synonymous	0.0351
Total	64

^aVariants with Fisher test values remaining significant after Bonferroni correction for the multiple testing for 1,377 variants (p-val ≤ 0.05/(1,377))