Table 5 Genes with variants showing significantly different pAAF between F2_F and F2_L

ADRB1

1

1 synonymous

0.0467

ALDH1B1

3

3 synonymous

0.0253

ALDH2

1

1 non-synoymous tolerated

0.0358

ALDH3B2

7

1 non-synoymous deleterious; 6 synonymous

0.0003–0.0137

ALDH6A1

1

1 synonymous

0.0253

CD36

3

1 frame-shift; 1 non-synoymous deleterious; 1 synonymous

1.5xE-05^a - 2.58xE-05^a

DISC1

3

3 synonymous

0.0280–0.0357

TVPR1 human ortholog (ENSSSCG00000017863)

5

1 non-synoymous deleterious; 4 synonymous

0.0111–0.0315

ALDH8A1 ortholog (ENSSSCG00000023457)

1

1 synonymous

0.0387

FOS

2

1 non-synoymous tolerated; 1 synonymous

0.0284

GABRA3

1

1 splice-site donor/acceptor

0.0253

GABRA6

1

1 synonymous

0.0047

GPR179

9

2 non-synoymous deleterious; 4 non-synoymous tolerated; 3 synonymous

0.0137–0.0324

GPRC5B

1

1 non-synoymous deleterious

0.0253

GPRC5C

1

1 non-synoymous tolerated

0.0258

GRM1

3

3 synonymous

0.0047–0.0383

GRM8

1

1 synonymous

0.0178

HTR1B

1

1 synonymous

0.0253

HTR3C

1

1 synonymous

0.0357

LEPR

1

1 synonymous

0.0253

MCHR2

2

2 synonymous

0.0115–0.0253

MTNR1B

1

1 non-synoymous tolerated

0.0357

P2RX2

2

2 synonymous

0.0094–0.0324

P2X7

3

3 synonymous

0.0006–0.0324

SIM1

1

1 synonymous

0.0115

TAS2R16 ortholog (ENSSSCG00000016433)

1

1 synonymous

0.0315

TAS2R39

1

1 codon change

6.16xE-08^a

TAS2R4

4

2 non-synoymous tolerated; 2 synonymous

0.0002–0.0158

TAS2R41

1

1 non-synoymous tolerated

0.0207

TAS2R60

1

1 synonymous

0.0351

Total

64