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Table 5 Genes with variants showing significantly different pAAF between F2_F and F2_L

From: Identification of protein-damaging mutations in 10 swine taste receptors and 191 appetite-reward genes

Gene Total number Number and type of variants with significant differences is pAAF Fisher Test value range (min-max)
ADRB1 1 1 synonymous 0.0467
ALDH1B1 3 3 synonymous 0.0253
ALDH2 1 1 non-synoymous tolerated 0.0358
ALDH3B2 7 1 non-synoymous deleterious; 6 synonymous 0.0003–0.0137
ALDH6A1 1 1 synonymous 0.0253
CD36 3 1 frame-shift; 1 non-synoymous deleterious; 1 synonymous 1.5xE-05a - 2.58xE-05a
DISC1 3 3 synonymous 0.0280–0.0357
TVPR1 human ortholog (ENSSSCG00000017863) 5 1 non-synoymous deleterious; 4 synonymous 0.0111–0.0315
ALDH8A1 ortholog (ENSSSCG00000023457) 1 1 synonymous 0.0387
FOS 2 1 non-synoymous tolerated; 1 synonymous 0.0284
GABRA3 1 1 splice-site donor/acceptor 0.0253
GABRA6 1 1 synonymous 0.0047
GPR179 9 2 non-synoymous deleterious; 4 non-synoymous tolerated; 3 synonymous 0.0137–0.0324
GPRC5B 1 1 non-synoymous deleterious 0.0253
GPRC5C 1 1 non-synoymous tolerated 0.0258
GRM1 3 3 synonymous 0.0047–0.0383
GRM8 1 1 synonymous 0.0178
HTR1B 1 1 synonymous 0.0253
HTR3C 1 1 synonymous 0.0357
LEPR 1 1 synonymous 0.0253
MCHR2 2 2 synonymous 0.0115–0.0253
MTNR1B 1 1 non-synoymous tolerated 0.0357
P2RX2 2 2 synonymous 0.0094–0.0324
P2X7 3 3 synonymous 0.0006–0.0324
SIM1 1 1 synonymous 0.0115
TAS2R16 ortholog (ENSSSCG00000016433) 1 1 synonymous 0.0315
TAS2R39 1 1 codon change 6.16xE-08a
TAS2R4 4 2 non-synoymous tolerated; 2 synonymous 0.0002–0.0158
TAS2R41 1 1 non-synoymous tolerated 0.0207
TAS2R60 1 1 synonymous 0.0351
Total 64   
  1. aVariants with Fisher test values remaining significant after Bonferroni correction for the multiple testing for 1,377 variants (p-val ≤ 0.05/(1,377))