Fig. 5

Validation of mutations in the KFRS4/Kyo strain. Each locus is compared with the corresponding locus in the closely related strain PVG/Seac. a The causative mutation for cataracts. A 5-bp insertion, which was previously reported as the causative mutation for cataracts in KFRS4/Kyo [28], was identified near the end of exon 1 of the Mip gene. b Deletion of a CNS responsible for congenital ear malformation in KFRS4/Kyo. This deletion, which was previously identified as the mutation responsible for congenital ear malformation [29], was located approximately 80-kb downstream of the Hmx1 gene