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Fig. 5 | BMC Genomics

Fig. 5

From: Comprehensive profiling of functional Epstein-Barr virus miRNA expression in human cell lines

Fig. 5

Gamma-herpesvirus miRNAs display less strand bias than host miRNAs. Box and whisker plots showing the miRNA arm ratios (deep sequencing read counts of the most abundant strand divided by the least abundant strand) in different cell lines. We limited the analysis to miRNAs with at least 1000 reads for the sum of both strands. The Tukey method was used for plotting the boxes, whiskers and outliers. miRNAs with one arm not detected are represented by a dot at the top of the graph (∞). a Arm ratios for human and EBV miRNAs in C666-1 cells. For the right six bars the miRNAs were divided in three different bins according to the read count number of the most abundant strand. b Arm ratios for human and EBV miRNAs in the EBV+ cell lines used in this study and EBV+ Akata-LCL and BC-1 cells (coinfected with EBV+ and KSHV+) deep sequenced in previous studies. c Arm ratios for KSHV/rhLCV and host miRNAs in BC-1 cells coinfected with EBV+ and KSHV+ and rhLCV infected rhesus macaque LCLs

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