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Table 2 Signaling pathways associated with differentially expressed proteins as identified by Pathway Studio program

From: A novel approach to assessing bisphenol-A hazards using an in vitro model system

Signaling Pathways

Overlapping Entities

P-value

Respiratory chain and oxidative phosphorylation

UQCRFS1, SDHB, COX6A1, ATP5O

<0.001

Glutathione metabolism

GSTM5, GPX4, PRDX5

0.017

Notch Pathway

ACTB, PPP1CA, HADHA, PGAM2, ODF1, GAPDH

0.017

EphrinR - > actin signaling

ACTB, ODF1

0.030

Adipocytokine Signaling

SDHB, HADHA, PGAM2, GAPDH

0.031

  1. BPA-induced differentially expressed proteins were entered into the Pathway Studio program to identify the significantly signaling pathways. The probabilities of the signaling pathways were determined using the Fisher’s exact test (p < 0.05)