Fig. 5
Validation of our network-based rhythmic gene and GO annotation predictions. a Pairwise overlaps between the 626 JTK_CYCLE-derived rhythmic genes that are in any of our networks, the network-based rhythmic genes predicted by the centrality analysis, and the network-based rhythmic genes predicted by the clustering analysis. Stars next to the overlap values indicate that all three pairwise overlaps are statistically significant, with p-values below 2×10−16, which validates our network approach. b Validation of our network-based rhythmic genes in terms of GO term overlaps with positive and negative control genes. Pairwise overlaps of enriched GO terms between the JTK_CYCLE-identified rhythmic genes, negative controls, and our novel network-based predictions produced by both centrality analysis and the clustering analysis. Also see Additional file 7