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Fig. 4 | BMC Genomics

Fig. 4

From: AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer

Fig. 4

Representation of the top Canonical Pathways, Functional Annotations and Upstream Regulators detected upon analysis of target genes and their co-regulated genes. A reconstructed gene network was created using the Ingenuity Pathway Analysis Software (IPA) on the basis of the target molecules, the molecules from the 10-top Canonical Pathways (see Table 4, Molecules) and the 10-top Upstream Regulators (see Table 8). Solid lines in grey display the IPA-identified direct interactions between the molecules; dashed lines display indirect interactions. The multigene approach-based correlation analysis was used to find additional biological associations between the target genes. Statistically significant study-based associations (SPSS program, Additional file 1: Table S5) are displayed by dashed lines; red for correlation coefficient ≥ 0.6, p < 0.001; blue for correlation coefficient < 0.6, p < 0.001. The 10-top Canonical Pathways are listed according to the IPA-based ranking (from left to right). For a complete overview, also the most significant Functional Annotations & Diseases are shown (see Tables 5, 6 and 7)

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