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Table 2 Comparative analysis of multivariable models (ridge) for prognostication of OS and PFS

From: AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer

 

OS

PFS

PEV %

c-index

P

PEV %

c-index

P

Clinics

8.77

0.69

<0.001

17.0

0.68

<0.001

AID/APOBEC

2.53

0.59

0.025

n.a.

n.a.

n.a.

Combined

11.13

0.70

<0.001; 0.021*

13.6

0.65

<0.001; 0.320*

  1. Cross-validated performance assessment of Cox regression models (ridge) by proportion of explained variation (PEV), concordance index (c-index) and p-value. Models were developed using (i) clinicopathological variables designated as Clinics; (ii) AID/APOBEC multigene-based variables designated as AID/APOBEC; (iii) their combination designated as Combined
  2. * p-value for added value of AID/APOBEC on top of Clinics in bivariable models with cross-validated predictors