From: AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer
Functional Annotations-10-top-output_mixed_and_3_individual | ||||||||
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Pos. | Functional Annotations | Mixed | APOBEC3G | ESR1 | ID2 | ID3 | PTPRC (CD45) | |
P-value | Molecules | Molecules | Molecules | Molecules | Molecules | Molecules | ||
1 | Rheumatic Disease | 1.66E-18 | ACTA2, AIF1, ALOX5, AR, BGN, C3AR1, CASP1, CCL5, CCR5, CD86, CDH11, CDKN1A, CIITA, COL1A1, COL6A1, CSF2RB, CTSS, FAS, FBN1, FCER1G, FCGRT, FN1, FSTL1, GBP2, GZMA, HCK, HLA-DOA, HLA-DPA1, HLA-DPB1, IGFBP4, IGFBP7, IL10RA, IL15, IRF1, ITGAM, ITPR1, JAM3, LST1, MS4A6A, PSMB9, PTPRC, SAMD9L, SDC2, SNAI2, SPOCK1, TAGAP, TIMP1, TLR3, TLR8, TNFSF13B, ZFP36 | Â | Â | ACTA2, CDH11, CDKN1A, COL1A1, COL6A1, FAS, FCGRT, IGFBP4, IGFBP7, SDC2, SNAI2, TIMP1, ZFP36 | BGN, CDH11, FBN1, FN1, IGFBP4, ITPR1, JAM3, SDC2, SNAI2, SPOCK1 | AIF1, C3AR1, CCL5, CCR5, CD86, CSF2RB, FCER1G, GZMA, HCK, IL10RA, LST1, MS4A6A, PTPRC, TLR8 |
2 | cell movement of leukocytes | 8.68E-17 | AIF1, ALOX5, AR, BGN, C3AR1, CASP1, CCL5, CCR5, CD2, CD47, CD48, CD86, CDKN1A, CIITA, COL1A1, CTGF, CTSS, CYBB, DOCK2, EGFR, ENG, EPS8, ESR1, FAS, FCER1G, FN1, FYB, HCK, IL10RA, IL15, ITGAM, JAM3, LCP2, PTPRC, RHOB, ROCK2, TIMP1, TLR3, TNFRSF14, TNFSF13B | ALOX5, CASP1, CCL5, CIITA, CTSS, IL15, ITGAM, TLR3, TNFSF13B | Â | CDKN1A, COL1A1, EGFR, ENG, EPS8, FAS, RHOB, ROCK2, TIMP1 | Â | AIF1, C3AR1, CCL5, CCR5, CD2, CD48, CD86, CYBB, DOCK2, FCER1G, FYB, HCK, IL10RA, LCP2 |
3 | quantity of leukocytes | 1.51E-16 | ALOX5, C3AR1, CCL5, CCR5, CD47, CD48, CD84, CD86, CDKN1A, CIITA, CLEC7A, CSF2RB, CTSS, CYBB, DKK3, DOCK2, ESR1, FAS, FCER1G, FOXP1, FYB, HCK, HEXB, ID1, ID2, IL10RA, IL15, IRF1, ITGAM, JAM3, LAIR1, LCP2, MEIS1, PSMB10, PSMB9, PTPRC, SAMSN1, SASH3, SLA, SNAI2, TIMP1, TLR3, TNFSF13B, ZFP36 | ALOX5, CCL5, CIITA, CLEC7A, CTSS, IL15, IRF1, ITGAM, PSMB10, PSMB9, TLR3, TNFSF13B | Â | CDKN1A, FAS, FOXP1, HEXB, ID1, ID2, SNAI2, TIMP1, ZFP36 | Â | C3AR1, CCL5, CCR5, CD48, CD84, CD86, CSF2RB, CYBB, DOCK2, FCER1G, FYB, HCK, IL10RA, LAIR1, LCP2, PTPRC, SAMSN1, SASH3, SLA |
4 | cell movement of myeloid cells | 4.14E-13 | AIF1, ALOX5, AR, C3AR1, CASP1, CCL5, CCR5, CD2, CD47, CD48, CDKN1A, COL1A1, CTGF, CTSS, CYBB, DOCK2, EGFR, ENG, FAS, FCER1G, FN1, HCK, IL15, ITGAM, JAM3, PTPRC, RHOB, ROCK2, TLR3 | ALOX5, CASP1, CCL5, CTSS, IL15, ITGAM, TLR3 | Â | CDKN1A, COL1A1, EGFR, ENG, FAS, RHOB, ROCK2 | Â | AIF1, C3AR1, CCL5, CCR5, CD2, CD48, CYBB, DOCK2, FCER1G, HCK |
5 | cell movement of phagocytes | 9.33E-13 | AIF1, ALOX5, AR, C3AR1, CASP1, CCL5, CCR5, CD47, CD86, CDKN1A, COL1A1, CTGF, CTSS, CYBB, DOCK2, EGFR, ENG, EPS8, FAS, FCER1G, FN1, HCK, IL10RA, IL15, ITGAM, JAM3, RHOB, TIMP1, TLR3 | ALOX5, CASP1, CCL5, CTSS, ITGAM, TLR3 | Â | CDKN1A, COL1A1, EGFR, ENG, EPS8, FAS, RHOB, TIMP1 | Â | AIF1, C3AR1, CCL5, CCR5, CD86, CYBB, DOCK2, FCER1G, HCK, IL10RA |
6 | cell death | 7.48E-11 | AIF1, ALOX5, ANTXR2, APOL6, AR, ARMC10, BGN, CASP1, CCL5, CCR5, CD2, CD47, CD48, CD53, CD86, CDH11, CDKN1A, CIITA, COL1A1, COL6A1, CSF2RB, CTGF, CTSS, CYBB, DKK3, DLC1, DPYD, EGFR, ENG, ESR1, EVA1C, EYA2, FAS, FBN1, FCER1G, FN1, FOXP1, FSTL1, GIMAP4, GZMA, HCK, HEXB, ID1, ID2, ID3, IFIH1, IGFBP4, IGFBP7, IL15, IRF1, ITGAM, ITPR1, LAIR1, LCP2, LRIG1, MEIS1, MNDA, MUC16, PMEPA1, PMP22, PTPRC, RHOB, ROCK2, SDC2, SGPP1, SNAI2, SOX17, SPOCK1, SULF2, TFEC, TIMP1, TLR3, TNFRSF14, TNFSF13B, VCAN, XAF1, ZFP36 | ALOX5, APOL6, CASP1, CCL5, CIITA, CTSS, DPYD, EVA1C, IFIH1, IL15, IRF1, ITGAM, TLR3, TNFRSF14, TNFSF13B, XAF1 | Â | ANTXR2, CDKN1A, COL1A1, COL6A1, CTGF, DLC1, EGFR, ENG, FAS, FOXP1, HEXB, ID1, ID2, ID3, IGFBP4, IGFBP7, RHOB, ROCK2, SDC2, SGPP1, SNAI2, SULF2, TIMP1, ZFP36 | Â | AIF1, CCL5, CCR5, CD2, CD48, CD53, CD86, CSF2RB, CYBB, FCER1G, GIMAP4, GZMA, HCK, LAIR1, LCP2, MNDA, PTPRC |
7 | metastasis | 1.05E-10 | ACTA2, AR, CASP1, CD47, CD86, CDKN1A, CTGF, CYBB, EGFR, ESR1, FN1, FOXP1, ID1, ID2, ID3, IGFBP7, IL15, IRF1, JAM3, MEIS1, NID2, PAPSS2, PRRX1, RAB31, RHOB, TIMP1, TLR8, VCAN | Â | AR, CD47, ESR1, MEIS1 | ACTA2, CDKN1A, CTGF, EGFR, FOXP1, ID1, ID2, ID3, IGFBP7, PAPSS2, RAB31, TIMP1 | FN1, ID1, ID2, ID3, JAM3, PRRX1 | Â |
8 | triple-negative breast cancer | 1.15E-10 | AR, CDH11, CDKN1A, CTGF, DLC1, EGFR, EPS8, ESR1, FAS, HCK, IRF1, LAMB1, TIMP1, WFDC2 | Â | AR, ESR1, WFDC2 | CDH11, CDKN1A, CTGF, DLC1, EGFR, EPS8, FAS, TIMP1 | CDH11, DLC1, LAMB1 | Â |
9 | binding of cells | 1.52E-10 | AR, BGN, CCL5, CCR5, CD2, CD47, CD48, CD84, CD86, CLEC7A, CSF2RB, ENG, FAS, FN1, FYB, HCK, HS3ST1, ITGAM, JAM3, LCP2, MUC16, PTPRC, RHOB, SDC2, SNX9 | Â | Â | ENG, FAS, HS3ST1, RHOB, SDC2, SNX9 | BGN, FN1, JAM3, RHOB, SDC2 | CCL5, CCR5, CD2, CD48, CD86, CSF2RB, FYB, HCK, LCP2, PTPRC |
10 | Lymphocyte migration | 2.14E-10 | ALOX5, CCL5, CCR5, CD2, CD47, CD48, CD86, COL1A1, CTSS, DOCK2, EGFR, ENG, FAS, FN1, FYB, IL15, JAM3, TIMP1, TNFRSF14, TNFSF13B | ALOX5, CCL5, IL15, TNFSF13B | Â | COL1A1, EGFR, ENG, FAS, TIMP1 | Â | CCL5, CCR5, CD2, CD48, CD86, DOCK2, FYB |