Fig. 4

The structure visualization page is divided to three panels. a The protein is shown in cartoon representation, and the input variant (light green) and database variants (red, yellow and green with the same color scheme of the sequence alignment) are shown in stick representation. The sequence alignment b is similar to that found in the hits’ page. Additional layers of information such as conservation, secondary structure and disorder may follow the sequences. Residues on the sequence can be marked on the structure diagram. The Control panel c provides easy access to some common graphical features, alternate visualization of the wild-type and the mutant structures and links to contact analyses and stability predictions