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Fig. 7 | BMC Genomics

Fig. 7

From: Global profiling of alternative RNA splicing events provides insights into molecular differences between various types of hepatocellular carcinoma

Fig. 7

Modifications to AS of 96 transcripts in response to knockdown of splicing factors with specific siRNAs. Using specific siRNAs, twelve splicing factors (U2AF2, SF3A2, RBM8A, RBM4, PRPF4B, NOVA1, KHSRP, HNRPU, HNRPL, HNRPH1, HNRPC, and HNRPA1) were individually knocked-down in different cell lines to assess their implication in splicing of 96 differents transcripts. Individual knockdowns and ASEs are shown to indicate which knockdowns caused a shift in alternative splicing in various cell lines (PC-3, SKOV3, NIH:OVCAR-3, MDA-MB-231, MCF7). Each column represents a distinct knockdown performed with specific siRNAs. The changes in PSI values are displayed. The map depicts the changes in PSI values in a color-coded scale. White areas indicate no shifts. Asterisks indicate transcripts for which AS was altered in HBV-associated HCC

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