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Fig. 11 | BMC Genomics

Fig. 11

From: Biochemical and cellular characterization of transcription factors binding to the hyperconserved core promoter-associated M4 motif

Fig. 11

Working model for the assembly of M4 binding factors on promoters of M4 genes. The M4 motif is composed of two highly conserved elements: an “upstream” ACTACR module (purple) and a “downstream” module TCCCRR (yellow), which constitute bipartite binding sites for THAP11 and Ikaros, respectively. Interaction between THAP11 and HCF-1 is required for recruiting HCF-1 to the M4 motif, whereas an interaction of Ikaros with NFKB1 (NF-kappa B p50) or NFKB2 (NF-kappa B p52) is essential for tethering these Rel TF family proteins to the M4 motif

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BMC Genomics

ISSN: 1471-2164

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