Table 3 Multivariate analysis of TRP53, phosphoserine-18-TRP53, phosphoserine-389-TRP53 and p38MAPK protein expression

TRP53

Sex

Female

ref

0.1805

Male

−0.028

−0.305

0.764249

Treatment

Control

ref

1.033E-10

High

1.02

11.110

6.23e-09

RAR

0.438

4.779

0.000205

Low

0.787

8.590

2.18e-07

Sex*Treatment

Male(Control)*Female(Control)

ref

0.2020

Male(High)*Female(High)

0.104

0.800

0.435191

Male(RAR)*Female(RAR)

−0.183

−1.417

0.175527

Male(Low)*Female(Low)

−0.065

−0.501

0.623391

phosphoserine-18-TRP53

Sex

Female

ref

0.0004246

Male

−0.126

−0.979

0.3420

Treatment

Control

ref

<2.2E-16

High

13.57

105.038

<2E-16

RAR

9.49091

73.469

<2E-16

Low

12.67

98.071

<2E-16

Sex*Treatment

Male(Control)*Female(Control)

ref

7.153E-11

Male(High)*Female(High)

0.516

2.825

0.0122

Male(RAR)*Female(RAR)

−2.101

−11.498

3.81e-09

Male(Low)*Female(Low)

0.947

5.185

9.03E-05

phosphoserine-389-TRP53

Sex

Female

ref

1.133E-05

Male

0.058

0.854

0.406

Treatment

Control

ref

<2.2E-16

High

4.041

59.194

<2E-16

RAR

7.419

108.665

<2E-16

Low

7.739

113.354

<2E-16

Sex*Treatment

Male(Control)*Female(Control)

ref

<2.2E-16

Male(High)*Female(High)

1.748

18.102

4.43E-12

Male(RAR)*Female(RAR)

0.909

9.416

6.30E-08

Male(Low)*Female(Low)

−2.035

−21.076

4.26E-13

phospho-Thr 180/Tyr 182-p38MAPK

Sex

Female

ref

1.196E-05

Male

4.586E-16

0.000

1.0000

Treatment

Control

ref

1.368E-15

High

−1.923e-01

−1.918

0.0732

RAR

1.291

12.874

7.38E-10

Low

−1.535e-01

−1.531

0.1453

Sex*Treatment

Male(Control)*Female(Control)

ref

3.259E-08

Male(High)*Female(High)

−1.257e-01

−0.886

0.3886

Male(RAR)*Female(RAR)

1.348

9.507

5.53E-08

Male(Low)*Female(Low)

2.765E-02

0.195

0.8479