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Table 3 Multivariate analysis of TRP53, phosphoserine-18-TRP53, phosphoserine-389-TRP53 and p38MAPK protein expression

From: Transcriptomic analysis reveals sex-specific differences in the expression of Dcl1 and Fis1 genes in the radio-adaptive response of thymocytes to TRP53-mediated apoptosis

Gene Variable Value Estimate t value p value p value*
TRP53 Sex Female ref    0.1805
Male −0.028 −0.305 0.764249  
Treatment Control ref    1.033E-10
High 1.02 11.110 6.23e-09  
RAR 0.438 4.779 0.000205  
Low 0.787 8.590 2.18e-07  
Sex*Treatment Male(Control)*Female(Control) ref    0.2020
Male(High)*Female(High) 0.104 0.800 0.435191  
Male(RAR)*Female(RAR) −0.183 −1.417 0.175527  
Male(Low)*Female(Low) −0.065 −0.501 0.623391  
phosphoserine-18-TRP53 Sex Female ref    0.0004246
Male −0.126 −0.979 0.3420  
Treatment Control ref    <2.2E-16
High 13.57 105.038 <2E-16  
RAR 9.49091 73.469 <2E-16  
Low 12.67 98.071 <2E-16  
Sex*Treatment Male(Control)*Female(Control) ref    7.153E-11
Male(High)*Female(High) 0.516 2.825 0.0122  
Male(RAR)*Female(RAR) −2.101 −11.498 3.81e-09  
Male(Low)*Female(Low) 0.947 5.185 9.03E-05  
phosphoserine-389-TRP53 Sex Female ref    1.133E-05
Male 0.058 0.854 0.406  
Treatment Control ref    <2.2E-16
High 4.041 59.194 <2E-16  
RAR 7.419 108.665 <2E-16  
Low 7.739 113.354 <2E-16  
Sex*Treatment Male(Control)*Female(Control) ref    <2.2E-16
Male(High)*Female(High) 1.748 18.102 4.43E-12  
Male(RAR)*Female(RAR) 0.909 9.416 6.30E-08  
Male(Low)*Female(Low) −2.035 −21.076 4.26E-13  
phospho-Thr 180/Tyr 182-p38MAPK Sex Female ref    1.196E-05
Male 4.586E-16 0.000 1.0000  
Treatment Control ref    1.368E-15
High −1.923e-01 −1.918 0.0732  
RAR 1.291 12.874 7.38E-10  
Low −1.535e-01 −1.531 0.1453  
Sex*Treatment Male(Control)*Female(Control) ref    3.259E-08
Male(High)*Female(High) −1.257e-01 −0.886 0.3886  
Male(RAR)*Female(RAR) 1.348 9.507 5.53E-08  
Male(Low)*Female(Low) 2.765E-02 0.195 0.8479  
  1. Sex*Treatment interaction term between sex and radiation treatment, ref reference value, Estimat e regression coefficient, t value t test values, p value* p value from F test in ANOVA analysis, High exposure to 1.75 Gy of g-rays, RAR radio-adaptive response, Low exposure to 0.075 Gy of X-rays