Fig. 1
From: Path2enet: generation of human pathway-derived networks in an expression specific context
Figure showing the NOTCH Signaling Pathway and the transformation into a network using Path2enet: (a) the canonical map included in the KEGG database (hsa:04330), showing all the distinct proteins that are included in each node of this pathway (total 48 proteins); (b) transfromation of the canonical pathway to a network done with Path2enet, that produces a new view incorporating all the information about the gene products that are expressed (i.e., active) based on the pathway and on the expression data sets of lymphocytes that are incorporated (163 samples: 32 B cells and 131 T cells). Path2enet uses the gene expression Barcode algorithm to evaluate if a gene is expressed (ON, yellow) in the network or not (OFF, white). The genes in blue correspond to NA (not assigned) since the tool could not assign them because they are not present in the expression platform used. The panels inside the figure indicate: "Edges" the characteristics of the links/relations that connect each node (blue, activation; red, inhibition; green, expression; black, other type of link); "Nodes" the expression level assigned to each node in the sample type studied that in this case were lymphocytes (white nodes, when their expression is below the threshold ≤0.4; yellow nodes, when their expression is above the threshold >0.4; blue nodes, when the expression level is not assigned)