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Fig. 1 | BMC Genomics

Fig. 1

From: The polymyxin B-induced transcriptomic response of a clinical, multidrug-resistant Klebsiella pneumoniae involves multiple regulatory elements and intracellular targets

Fig. 1

Transcriptomic response of Klebsiella pneumoniae Kp13 to different environmental stimuli. a The outer rings organized as pseudo-chromosomes harbor differentially expressed genes respective to the PB condition, except for the red ring representing the union of the conditions. Links from the top 10 % DE (up- and down-regulated) genes to the union of conditions are depicted, and for each condition a heatmap of expression of each gene (in log2[fold-change] scale) is shown. Below the union of the conditions an histogram of the frequency of DE genes is shown (i.e. if a gene appears DE in all conditions a value of five is shown in the histogram). Selected gene labels are shown on the innermost ring, question marks denote hypothetical genes being found differentially expressed. b, c Venn diagram showing the differentially expressed up- (Panel b) and down-regulated (Panel c) genes in the different conditions relative to PB. Criteria for significance: FDR≤0.01. The image was prepared with Circos [67] and jvenn [68]

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