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Fig. 4 | BMC Genomics

Fig. 4

From: The polymyxin B-induced transcriptomic response of a clinical, multidrug-resistant Klebsiella pneumoniae involves multiple regulatory elements and intracellular targets

Fig. 4

Diagram showing the response of K. pneumoniae Kp13 to PB and PB with acid pH. High polymyxin B concentration (left side) and high polymyxin B concentration with acid pH (right side). The mechanisms involved in Kp13’s response in both culture conditions are described in this manuscript. These mechanisms were ranging from LPS modification, capsule and adhesion production, metabolic shift aerobic to fermentation, efflux pump and beta-lactamases overexpression, regulation of iron metabolism (ferritin-like protein), acid response and DNA damage repair

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