Fig. 1
From: CNARA: reliability assessment for genomic copy number profiles
An example of simulated copy number profiles. Samples of 10,000 dimensions (n=10,000) were generated for 3 reliability groups, i.e. A: reliable copy number profiles containing many CNAs; B: unreliable copy number profiles having indiscernible CNAs due to wave artefacts; C: hyper-segmented copy number profiles. In group A, both CBS and step-fitting recovered majority of copy number segments well; In group B, both methods fitted noise and CBS detected more change-points than step-fitting; In group C, CBS detected too many change-points whereas step-fitting recovered majority of segments well