Fig. 1

Differentially expressed candidate genes in MI. a CATHGEN. P-value of association between expression of probe ID (labeled by assigned gene) and MI status from logistic regression with age, race, and gender as additional covariates. Genes with p-value less than 0.05 are colored in red. b Framingham Heart Study. Number of resamples (of total 5000) in which mRNA expression of GWAS-based candidate gene was significantly associated with MI (p < 0.05) in conditional logistic regression model. Controls were matched to cases on age, gender, and belonging to a different family. TRIB1, VAMP8, FES, PHACTR1, ZEB2, NT5C2, and SMG6 (colored in red) had expression profiles strongly associated with MI (i.e. median p-value among bootstrap replicates < 0.05). c Histograms of p-values for genes determined as significant in CATHGEN that did not meet the criteria for being associated with MI in FHS. FURIN, IL6R, RAI1, and UBE2Z were informative of MI based on right-skewed histogram. d Venn diagram displaying overlap between genes individually significant in CATHGEN and the Framingham Heart Study