Fig. 2

Odds ratios and conditional odds ratios of MI for non-linearly interacting pairs. a Conditional odds ratios of MI from one standard deviation increase in the mean expression of gene A, plotted against expression of the second interacting gene, gene B. Histograms of gene B expression are displayed above each panel. The odds ratio is defined as:odds(Ex_A + sd(Ex_A))/odds(Ex_A) where Ex_A and sd(Ex_A) denote the expression level and the standard deviation of expression of gene A respectively. Red lines indicate an odds ratio of 1. In panel b the interaction is displayed as surface plot, which is a three dimensional plot of expression of the two genes versus the log-odds of MI. The curvature of the saddle shape surface indicates the magnitude of the interaction term in the model