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Fig. 3 | BMC Genomics

Fig. 3

From: Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles

Fig. 3

Differentially expressed candidate gene pairs in MI. Nodes are genes and edges reflect significant non-linear interactions defined by logistic models (see Methods). Pink nodes indicate genes that are individually significant (see Fig. 1), red lines indicate gene pairs that are co-expressed (see Fig. 4), dotted lines indicate gene pairs that were not tested for co-expression due to poor expression of one or more of the genes, bolded edges indicate non-linear interactions identified in both cohorts (CNNM2|GUCY1A3; CNNM2|ZEB2). a CATHGEN. Connected graph formed by pairs of genes with a significant interaction term in CATHGEN using a logistic model (logit(MI) ~ RNA1 + RNA2 + RNA1*RNA2 + additional covariates). b Framingham Heart Study. Disconnected graphs formed by pairs of genes exhibiting statistically significant interaction terms in FHS, defined by means of the bootstrapped conditional logistic regression (logit(MI) ~ RNA1 + RNA2 + RNA1*RNA2) with 5000 repetitions and matching procedure the same as for individual genes

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