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Table 2 Interactions between candidate gene pairs in the Framingham Heart Study

From: Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles

 

Percent significant resamples

Additive Model

Interaction Model

Gene1

Gene2

Gene1

Gene2

Gene1*

Gene2

CNNM2|GUCY1A3

1 %

2 %

89 %

89 %

86 %

CNNM2|PEMT

1 %

1 %

54 %

54 %

54 %

CNNM2|ZEB2

0 %

75 %

56 %

51 %

56 %

IL6R|LPAL2

9 %

1 %

56 %

59 %

60 %

MIA3|SLC22A5

1 %

5 %

84 %

75 %

84 %

MIA3|ZC3HC1

1 %

2 %

58 %

45 %

57 %

  1. Percent of significant resamples (p < 0.05) for each term in 5000 repetitions of conditional logistic regression. Additive model: MI as explained by main effects of candidate genes (logit(MI) ~ RNA1 + RNA2). Interactive model: MI as explained by main effects of candidate genes and an interaction term (logit(MI) ~ RNA1 + RNA2 + RNA1*RNA2)