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Fig. 3 | BMC Genomics

Fig. 3

From: Genome-wide identification and characterisation of HOT regions in the human genome

Fig. 3

Developmental persistence of HOT regions at embryonic enhancers a Mouse day 11.5 embryonic tissue activity (blue lacZ staining) of seven representative transgenic human enhancer elements from the VISTA database. Shown below each image are the enhancer ID and numbers of individual embryos with enhancer activity (staining) in the indicated anatomical structure. b DNaseI hypersensitivity at seven enhancer elements corresponding to a across 57 definitive cell types. Note the relationship between the anatomical staining patterns in a and the cellular restriction (or lack thereof) of DNaseI hypersensitivity. c-d Persistence of HOT regions at embryonic enhancers. c Percentage of validated embryonic enhancers from the VISTA database with blood vessel staining (“Blood vessels”) and without blood vessel staining (“NOT Blood vessels”) that overlap a HOT region in any human endothelial cell type. d Percentage of validated embryonic enhancers from the VISTA database with heart staining (“Heart”) and without heart staining (“NOT Heart”) that overlap a HOT region in any human paraxial mesoderm cell type

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