Fig. 1
From: AP-SKAT: highly-efficient genome-wide rare variant association test
A sample figure exemplifying the distribution of the expectation of the estimated p-value and the stop criteria in the proposed procedure. The α confidence interval d α of the distribution of the estimated p-value \(\hat {p}\) is colored gray. B and r are the number of permutations completed and the number of permutation statistics that are greater than the original statistic s using the observed data, respectively. The stop criterion is evaluated using p±d α /2 and α p , which is the predefined significance level