Table 1 The power comparison of SKAT, SKAT-O, and AP-SKAT aimed at testing the association between randomly selected 5 kb regions and continuous traits under the effect size = 0.4
From: AP-SKAT: highly-efficient genome-wide rare variant association test
SKAT | SKAT-O | AP-SKAT | |||||||
|---|---|---|---|---|---|---|---|---|---|
|  | 10−2 | 10−3 | 10−4 | 10−2 | 10−3 | 10−4 | 10−2 | 10−3 | 10−4 |
250 | 1.47E-2 | 1.67E-3 | 1.89E-4 | 1.48E-2 | 1.69E-3 | 1.95E-4 | 1.51E-2 | 1.80E-3 | 2.40E-4 |
500 | 2.13E-2 | 2.90E-3 | 4.03E-4 | 2.15E-2 | 2.92E-3 | 4.03E-4 | 2.17E-2 | 3.07E-3 | 4.91E-4 |
750 | 2.92E-2 | 4.67E-3 | 7.35E-4 | 2.94E-2 | 4.69E-3 | 7.38E-4 | 2.97E-2 | 4.74E-3 | 8.37E-4 |
1000 | 3.84E-2 | 6.86E-3 | 1.24E-3 | 3.86E-2 | 6.95E-3 | 1.25E-3 | 3.91E-2 | 7.08E-3 | 1.33E-3 |
1250 | 4.92E-2 | 9.60E-3 | 1.92E-3 | 4.93E-2 | 9.72E-3 | 1.92E-3 | 4.95E-2 | 9.71E-3 | 2.05E-3 |
1500 | 6.05E-2 | 1.31E-2 | 2.81E-3 | 6.07E-2 | 1.31E-2 | 2.82E-3 | 6.14E-2 | 1.32E-2 | 3.05E-3 |