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Table 1 The power comparison of SKAT, SKAT-O, and AP-SKAT aimed at testing the association between randomly selected 5 kb regions and continuous traits under the effect size = 0.4

From: AP-SKAT: highly-efficient genome-wide rare variant association test

SKAT SKAT-O AP-SKAT
  10−2 10−3 10−4 10−2 10−3 10−4 10−2 10−3 10−4
250 1.47E-2 1.67E-3 1.89E-4 1.48E-2 1.69E-3 1.95E-4 1.51E-2 1.80E-3 2.40E-4
500 2.13E-2 2.90E-3 4.03E-4 2.15E-2 2.92E-3 4.03E-4 2.17E-2 3.07E-3 4.91E-4
750 2.92E-2 4.67E-3 7.35E-4 2.94E-2 4.69E-3 7.38E-4 2.97E-2 4.74E-3 8.37E-4
1000 3.84E-2 6.86E-3 1.24E-3 3.86E-2 6.95E-3 1.25E-3 3.91E-2 7.08E-3 1.33E-3
1250 4.92E-2 9.60E-3 1.92E-3 4.93E-2 9.72E-3 1.92E-3 4.95E-2 9.71E-3 2.05E-3
1500 6.05E-2 1.31E-2 2.81E-3 6.07E-2 1.31E-2 2.82E-3 6.14E-2 1.32E-2 3.05E-3