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Table 4 The power comparison of SKAT, SKAT-O, and AP-SKAT aimed at testing the association between randomly selected 5 kb regions and continuous traits under the effect size = 1.6

From: AP-SKAT: highly-efficient genome-wide rare variant association test

SKAT SKAT-O AP-SKAT
  10−2 10−3 10−4 10−2 10−3 10−4 10−2 10−3 10−4
250 2.19E-1 8.09E-2 2.90E-2 2.21E-1 8.30E-2 2.95E-2 2.24E-1 8.32E-2 2.97E-2
500 4.84E-1 3.05E-1 1.63E-1 4.80E-1 3.04E-1 1.64E-1 4.85E-1 3.01E-1 1.67E-1
750 5.99E-1 4.83E-1 3.69E-1 5.99E-1 4.82E-1 3.71E-1 6.09E-1 4.80E-1 3.66E-1
1000 7.42E-1 5.42E-1 4.88E-1 7.41E-1 5.42E-1 4.89E-1 7.48E-1 5.46E-1 4.87E-1
1250 8.50E-1 6.52E-1 5.14E-1 8.50E-1 6.54E-1 5.13E-1 8.50E-1 6.54E-1 5.16E-1
1500 9.19E-1 7.50E-1 5.93E-1 9.20E-1 7.48E-1 5.90E-1 9.18E-1 7.48E-1 5.94E-1