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Table 5 The power comparison of SKAT, SKAT-O, and AP-SKAT aimed at testing the association between randomly selected 5 kb regions and continuous traits under the effect size = 2.0

From: AP-SKAT: highly-efficient genome-wide rare variant association test

SKAT SKAT-O AP-SKAT
  10−2 10−3 10−4 10−2 10−3 10−4 10−2 10−3 10−4
250 3.77E-1 2.00E-1 8.70E-2 3.82E-1 2.01E-1 8.84E-2 3.83E-1 1.97E-1 8.88E-2
500 6.14E-1 4.89E-1 3.88E-1 6.14E-1 4.90E-1 3.88E-1 6.24E-1 4.89E-1 3.79E-1
750 8.16E-1 6.12E-1 5.01E-1 8.16E-1 6.07E-1 5.01E-1 8.16E-1 6.14E-1 5.02E-1
1000 9.30E-1 7.68E-1 6.10E-1 9.30E-1 7.66E-1 6.11E-1 9.27E-1 7.69E-1 6.12E-1
1250 9.81E-1 8.96E-1 7.48E-1 9.80E-1 8.94E-1 7.42E-1 9.78E-1 8.78E-1 7.42E-1
1500 9.95E-1 9.61E-1 8.58E-1 9.95E-1 9.60E-1 8.59E-1 9.94E-1 9.48E-1 8.49E-1