Acquisition and loss of virulence-associated factors during genome evolution and speciation in three clades of Bordetella species

Table 3 Presence and absence of specific virulence-associated key factors in the genomes of 9 Bordetella species

Key factor\Species	B. bronchiseptica	B. parapertussis	B. pertussis	B. holmesii	B. hinzii	B. avium	B. trematum	B. petrii	B. ansorpii
BvgA/BvgS/FHA	+	+	+	+	+	+	+	+	-
DNT	45/58	+	+	-	-	+	-	-	-
T1SS-ACT	55/58	+	+	-	-	-	-	-	-
T2SSa	-	-	-	-	+	+	-	2/3	+
T2SSb	-	-	-	-	-	-	-	-	+
T2SSc	-	-	-	-	-	-	-	-	1/2
Type IV Pilus A	+	+	d	d	+	d	-	+	+
Type IV Pilus B	+	+	d	d	+	+	+	+	+
Type IV Pilus C	+	+	d	d	+	+	+	+	+
Type IV Pilus D	+	1/2	-	-	-	-	-	-	-
Type IV Pilus E	-	-	-	-	-	-	-	-	+
Type IV Pilus F	-	-	-	-	-	-	-	-	+
T3SS	+	+	+	-	-	-	-	-	+
T4SS-Pertussis Toxin	42/58	d	+	-	-	-	-	-	-
T5SS-Pertactin	+	+	+	-	-	-	-	-	-
T6SSa	51/58	+	-	-	-	-	-	+	+
T6SSb	-	-	-	-	5/6	+	-	-	-
T6SSc	-	-	-	-	-	-	-	1/3	-
O-antigenA (wbm locus)^a	51/58	1/2	-	-	-	-	-	-	-
O-antigenB (BAV0081-89)	-	-	-	-	-	+	-	-	-
Capsule A	+	+	+	+	+	-	-	-	-
Capsule B	-	-	-	-	+	+	+	-	-
Capsule C	-	-	-	-	-	-	-	-	1/2
Cellulose synthesis	-	-	-	-	+	+	+	-	+
Flagella	+	1/2	+	-	+	+	+	+	+
Alcaligin receptor	+	+	+	+	-	-	-	-	-
Heme receptor	+	+	+	+	+	+	+	-	d
Enterobactin receptor	+	d	+	+	+	+	+	+	-

d degenerate, likely not functional
^a- B. trematum and B. ansorpii may potentially contain other, additional O-antigen synthesis loci

ISSN: 1471-2164