Fig. 4

Genes are edited in miRNA-targeted mRNA regions in a stage-specific fashion. a Heatmaps of the percentage of cells edited at each stage (left) and P-values by Fisher’s exact tests (excluding pronucleus stage for insufficient cells) on the number of edited and unedited cells between a specific stage and other stages (right). Vertical bars highlight the genes that are more frequently edited in miRNA-targeted regions at one (black) or two sequential stages (blue) than other stages. Arabic numeral denotes the number of genes in each group. b and c Heatmaps of the frequencies of cells edited on genes involved in cell cycle and in generic transcription pathway, respectively. Each column represents an embryonic stage, and each row represents a gene