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Table 6 ISS vs ISE conservation across various exon sets

From: Does conservation account for splicing patterns?

Regime ISS med. ISE med. Diff More cons‘d p
(a) Upstream (35 ISSs, 7 ISEs)
All 0.004 0.005 -0.001 ISEs 2e-39
Old- 0.001 0.003 -0.002 ISEs 4e-83
Old+ 0.987 0.995 -0.008 ISEs 2e-5
New 0.007 0.002 0.005 ISSs 1e-56
High Ψ 0.001 0.004 -0.003 ISEs 1e-108
Low Ψ 0.013 0.011 0.002 ISEs 3e-5
(b) Downstream (85 ISSs, 16 ISEs)
All 0.003 0.002 0.001 ISSs 4e-48
Old- 0.001 0.001 0 ISEs 1e-5
Old+ 0.994 0.990 0.004 ISSs 0.0003
New 0.006 0.002 0.004 ISSs 4e-91
High Ψ 0.001 0.001 0 ISEs 6e-16
Low Ψ 0.007 0.006 0.001 0.4
  1. Median of conservation scores across all bases that are part of any ISS/ISE, and which distribution of scores is larger according to a Mann-Whitney test. Upstream ISEs are more conserved than ISSs and downstream ISSs are more conserved than ISEs. Despite this difference, ISSs are more conserved near new exons both upstream and downstream, suggesting that intronic regulatory elements are at least partially responsible for the low percent inclusion of this set of exons