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Table 6 ISS vs ISE conservation across various exon sets

From: Does conservation account for splicing patterns?

Regime

ISS med.

ISE med.

Diff

More cons‘d

p

(a) Upstream (35 ISSs, 7 ISEs)

All

0.004

0.005

-0.001

ISEs

2e-39

Old-

0.001

0.003

-0.002

ISEs

4e-83

Old+

0.987

0.995

-0.008

ISEs

2e-5

New

0.007

0.002

0.005

ISSs

1e-56

High Ψ

0.001

0.004

-0.003

ISEs

1e-108

Low Ψ

0.013

0.011

0.002

ISEs

3e-5

(b) Downstream (85 ISSs, 16 ISEs)

All

0.003

0.002

0.001

ISSs

4e-48

Old-

0.001

0.001

0

ISEs

1e-5

Old+

0.994

0.990

0.004

ISSs

0.0003

New

0.006

0.002

0.004

ISSs

4e-91

High Ψ

0.001

0.001

0

ISEs

6e-16

Low Ψ

0.007

0.006

0.001

0.4

  1. Median of conservation scores across all bases that are part of any ISS/ISE, and which distribution of scores is larger according to a Mann-Whitney test. Upstream ISEs are more conserved than ISSs and downstream ISSs are more conserved than ISEs. Despite this difference, ISSs are more conserved near new exons both upstream and downstream, suggesting that intronic regulatory elements are at least partially responsible for the low percent inclusion of this set of exons