Fig. 3

Profiling of histone marks across type I BDPs and UDP controls with the same gene number and expression level as the bidirectional gene pairs. Unidirectional genes with higher and lower FPKM values were aligned on the right and left side, respectively (Fig. 3 b, d and f). Bidirectional gene pairs with higher and lower FPKM values were aligned on the right and left sides of the BDPs, respectively (Fig. 3 a, c and e). Normalized reads counts indicated the enrichment of each mark were calculated by reads number per bp of genomic region per million reads. X-axes show the relative distances of BDPs (bp) in Fig. 3 a, c and e and their positions relative to the TSSs in Fig. 3 b, d and f; Y-axes show normalized reads counts (read number in per bp of genome per million reads) within 1 kb upstream and downstream of the TSS. a. Profiles of active marks: H4K12ac, H3K27ac, H3K4ac and H3K9ac in type I BDPs (Fig. 3 a) and UDPs (Fig. 3 b). b. Profiles of active marks: H3K4me2, H3K4me3 and H3K36me3 in type I BDPs (Fig. 3 c) and UDPs (Fig. 3 d). c. Profiles of repressive marks: H3K9me1, H3K9me3 and H3K27me3 in type I BDPs (Fig. 3 e) and UDPs (Fig. 3f )