Differential gene expression in Varroa jacobsoni mites following a host shift to European honey bees ( Apis mellifera )

Table 5 Most specific GO terms related to mite genes that are down-regulated in the A. mellifera host, cluster 1

GO-ID	Term	Category	P-Value	Am-down seq. count^a	Ref seq. count^b
GO:0060237	regulation of fungal-type cell wall organization	P	0.000611	1	1
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	F	0.000102	2	56
GO:0000987	core promoter proximal region sequence-specific DNA binding	F	0.000181	2	75
GO:0001159	core promoter proximal region DNA binding	F	0.000195	2	78
GO:0048546	digestive tract morphogenesis	P	0.000440	2	118
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	F	0.000549	2	132
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	F	0.000697	2	149
GO:0001012	RNA polymerase II regulatory region DNA binding	F	0.000782	2	158
GO:0048565	digestive tract development	P	0.001380	2	211
GO:0055123	digestive system development	P	0.001610	2	228

Fisher’s exact test showing enriched GO terms in mite genes that are down-regulated in A. mellifera host (cluster 1). For a complete list and gene ID see (Additional file 5: Table S5). ^a23 genes in test set ^bnumber of times the GO was identified in reference set of 37,661 genes