Distinct gene expression program dynamics during erythropoiesis from human induced pluripotent stem cells compared with adult and cord blood progenitors

Table 2 Genes differentially expressed (DE) (B value at least 2.945, p-value below 0.01, fold change at least 2, and expression levels in all replicates at any population at least 100) during maturation of adult erythroblasts in SEM-F were selected as shown, and submitted to gene ontology analysis using GeneCoDis

Comparison	GO category	Corrected Hyp. p Value
Upregulated d0 to d4	Mitotic cell cycle	2e⁻⁹¹
Downregulated d0 to d4	Cytokine-mediated signalling	7e⁻²⁰
Downregulated d0 to d4	Antigen processing and presentation	7e⁻¹⁸
Upregulated d12 to d14	Nucleus/cell cycle arrest	7e⁻⁶
Downregulated d12 to d14	Purine metabolism	4e⁻¹¹
	Ribosome biosynthesis	8e⁻⁹
	Mitotic cell cycle	7e⁻⁸

Significantly-scoring ontologies are shown, together with p-values presented as the more stringent corrected hypergeometric (Hyp) p-values produced by GeneCoDis

ISSN: 1471-2164