Table 2 Enrichment of known acute kidney injury (AKI)-relevant genes in module clusters
From: Mining kidney toxicogenomic data by using gene co-expression modules
Module cluster | No. of genes in module cluster | No. of AKI genes | p-value | AKI-relevant genes |
|---|---|---|---|---|
1 | 184 | 0 | 1.00 | - |
2 | 164 | 1 | 0.67 | CYP2D6 |
3 | 217 | 7 | 0.0008 | ALB, AMBP, CYP2C19, CYP2C9, CYP2D6, FABP1, GSTP1 |
4 | 181 | 0 | 1.00 | - |
5 | 70 | 0 | 1.00 | - |
6 | 286 | 1 | 0.88 | PPARG |
7 | 273 | 7 | 0.002 | B2M, CD44, GPNMB, G6PD, GSTP1, HAVCR1, TFF3 |
8 | 197 | 1 | 0.78 | HEXB |
9 | 320 | 0 | 1.00 | - |
10 | 136 | 0 | 1.00 | - |
11 | 517 | 10 | 0.002 | A2M, CLU, CD44, GPNMB, GAS6, HAVCR1, LCN2, SPP1, TNFRSF12A, TFF3 |
12 | 217 | 0 | 1.00 | - |
13 | 509 | 2 | 0.89 | AMN, OCLN |
14 | 509 | 5 | 0.34 | A2M, EPO, GSTM2, LCN2, SPP1 |
15 | 379 | 0 | 1.00 | - |
16 | 181 | 0 | 1.00 | - |