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Table 1 Targeted sequencing panels and the analyzed genes associated with gastric cancer

From: Comparison between two amplicon-based sequencing panels of different scales in the detection of somatic mutations associated with gastric cancer

Panel name Targets size No. of Amplicons No. of genes Covered rate Gene list
Selective hotspot Panel 38.01 kb 376 20 99.99 % APC*, ARID1A, BCOR, CDH1*, CTNNB1*, EGFR*, ERBB2*, ERBB3, FGFR2*, JAK2*, KRAS*, MET*, NRAS*, PIK3CA*, PTEN*, RASA1, RHOA*, RNF43, SMAD4*, TP53*
Comprehensive Panel 351.05 kb 3515 58 96.86 % ABCA10, ACVR2A, AKAP13, APC , ARHGAP5, ARID1A , BCOR , BNC2, CD274, CDH1 , CNGA4, CTNNA1, CTNNA2, CTNNB1* , DLC1, DNAH7, EGFR , EIF2C4, ELF3, ERBB2 , ERBB3 , EYA4, FAM46D, FAT4, FGFR1, FGFR2 , GLI3, JAK2 , KIF2B, KMT2A, KMT2C, KRAS* , LDOC1, MACF1, MET , MUC6, NRAS* , PCDH9, PDCD1LG2, PIK3CA , PIK3R1, PKHD1, PLB1, PTEN , PTPRC, RASA1 , RGNEF, RHOA* , RNF43 , SMAD2, SMAD4 , SOHLH2, SYNE1, TGFBR2, TMPRSS2, TP53 , VEGFA, ZIC4
  1. Genes shown in bold font represent the 20 identified by the Selective hotspot Panel
  2. *Genes targeting hotspot regions