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Table 3 P-values for four different effect tests

From: A new statistical framework for genetic pleiotropic analysis of high dimensional phenotype data

Outcome

Causal

Stability

P-value for path coefficient

P-value (Single trait marginal)

Min (P-value) PCA

P-value (Multiple traits marginal)

     

1.44E-03

1.57E-03

SBP

PIK3R5

1

8.38E-05

9.25E-02

  

DBP

PIK3R5

1

1.20E-03

7.62E-02

  

TRIGS

PIK3R5

0.9

5.59E-03

1.07E-01

  

FASTGLUCOSE

PIK3R5

0.9

1.31E-02

2.01E-01

  

BMI

PIK3R5

0.88

1.63E-02

2.61E-01

  

FASTINSULIN

PIK3R5

0.92

3.00E-02

7.94E-01

  

HDL

PIK3R5

0.81

3.84E-02

2.39E-01

  
     

2.17E-04

2.43E-04

DBP

HS1BP3

0.96

1.21E-04

1.58E-01

  

HDL

HS1BP3

0.98

6.78E-04

8.15E-04

  

SBP

HS1BP3

0.87

6.08E-03

9.10E-01

  

BMI

HS1BP3

0.94

1.71E-02

1.91E-01

  

FASTGLUCOSE

HS1BP3

0.91

1.99E-02

5.95E-02

  
     

4.79E-04

5.24E-04

DBP

ABCC9

1

5.30E-06

6.49E-02

  

SBP

ABCC9

0.94

2.56E-04

4.63E-01

  

FASTINSULIN

ABCC9

0.95

2.71E-03

2.10E-03

  

FIBRINOGEN

ABCC9

0.96

5.52E-03

7.71E-02

  
  1. The tested p-value for the path coefficient, mariginal effects of single trait and multiple traits, and minimum of P-values from PCA analysis (example of three genes that connected to more than four phenotypes)