Fig. 4
Genetic organization of swr biosynthetic gene cluster and proposed biosynthetic pathway for serrawettin W2 identified in YD25T. Model for the biosynthesis of serrawettin W2 showing the structures of some of the proposed intermediates. SwrEFG, and SwrA form a hybrid PKS-NRPS system, which consists of five modules as indicated. Underneath the genes are the relative size, module and domain organization, and their predicted products of the PKS-NRPS. The amino acids are predicted to be incorporated into serrawettin W2 peptide moiety based on specific signature sequences in each A-domain. Domains within the PKS-NRPS are as follows. AT: acyltransferase; KS, ketosynthase; KR: ketoreductase; A: adenylation; C: condensation; T: thiolation; TE: thioesterase